| STUDYID | STOREDB:STUDY1014 |
|---|---|
| CREATEDON | 2015-12-10 16:16:02 |
| MODIFIEDON | 2015-12-10 16:16:02 |
| UPLOADER | Michael Gruenberger |
| DOI | DOI:10.20348/STOREDB/1014 |
| STUDY NAME | ||
|---|---|---|
| Comparative Toxicity and Retention of Am-241, Pu-239, and U-233 in Mice | ||
| STUDY STATUS | ||
| Published: Open access to everyone | ||
| DATA SHARING POLICY | ||
| CC-Attribution Non-Commercial Share Alike | ||
| COUNTRY | ||
| United Kingdom | ||
| PRINCIPAL INVESTIGATOR | ||
| Dr Michele Ellender | ||
| SPECIES | ||
| Mus musculus | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| Yes | ||
| STUDY DESCRIPTION | ||
| Aim: To determine the long-term risks from contamination by different alpha emitters Treatment: Nine i.p. injections of Am-241 citrate, Pu-239 citrate or U-233 citrate (the activity was given as 9 injections over a short period to avoid any toxic effects due to the chemical toxicity of uranium; all groups were treated similarly)Dosimetry: Activities calculated to give the same average bone dose at 500 days at each group on the basis of data on distribution and retention (serial killing 1, 7, 14, 28, 112, 224,448 days) Endpoints: Life-span study with macroscopic/microscopic pathologyAnimal: Male CBA/H mice aged 12 weeksResults: Statistical modelling by Cox regression showed that, considering all three nuclides together, there was a highly significant increase in hazard of death from osteosarcoma or myeloid leukaemia with increasing dose rate. For osteosarcoma, the effect was significantly greater for 239Pu than for241Am. The analysis for233U was statistically consistent with no effect of dose rate. For example, the increase in relative hazard of death from osteosarcoma for an increase in dose rate of 1 mGy/d was 4.2 (2.7 - 6.5) for239Pu, 2.3 (1.4 - 3.4) for241Am and 1.1 (0.4 - 3.1) for233U. For myeloid leukaemia there was no significant difference between 239Pu and 241Am in the effect of dose rate. The increase in relative hazard from myeloid leukaemia for an increase in dose rate of 1 mGy/d was 1.8 (1.1 - 2.8) for239Pu, 2.0 (1.4 - 2.9) for241Am and 1.5 (0.8 - 2.7) for233U. Significant increases in hepatic (241Am) and renal (233U) carcinoma were also recorded.Studies of the distribution of the nuclides within the skeleton showed differences in their retention in individual bones and within bone. The proportions of I-decays occurring near to bone surfaces and in bone marrow were in the order: 239Pu > 241Am > 233U, For osteosarcoma, the relative effectiveness of the nuclides was consistent with the proportion of dose delivered near to endosteal surfaces. For myeloid leukaemia, the greater effectiveness of 239Pu and 241Am compared to 233U was consistent with their accumulation in the marrow.
https://era.bfs.de/studies_description_from_db.php?LabId=8 | ||
| DATASET NAME | ||
|---|---|---|
| Zoomable histopathology images | ||
| DOI | DOI:10.20348/STOREDB/1014/1028 | |
| LINK TO FILE | ||
| http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2324 | ||
| DATASET DESCRIPTION | ||
| Mouse number M1305
Control. Hemangiosarcoma, knee | ||
| DATASET NAME | ||
|---|---|---|
| Zoomable histopathology images | ||
| DOI | DOI:10.20348/STOREDB/1014/1027 | |
| LINK TO FILE | ||
| http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2322 | ||
| DATASET DESCRIPTION | ||
| Mouse number M1275
Control. Gut intusseption | ||
| DATASET NAME | ||
|---|---|---|
| Zoomable histopathology images | ||
| DOI | DOI:10.20348/STOREDB/1014/1026 | |
| LINK TO FILE | ||
| http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2321 | ||
| DATASET DESCRIPTION | ||
| Mouse number M1265
Control. Odontoma. Jaw | ||
| DATASET NAME | ||
|---|---|---|
| Zoomable histopathology images | ||
| DOI | DOI:10.20348/STOREDB/1014/1025 | |
| LINK TO FILE | ||
| http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2320 | ||
| DATASET DESCRIPTION | ||
| Mouse number M1262
Control. Hemangiosarcoma, lumbar vertebrae | ||
| DATASET NAME | ||
|---|---|---|
| Zoomable histopathology images | ||
| DOI | DOI:10.20348/STOREDB/1014/1024 | |
| LINK TO FILE | ||
| http://131.111.180.187/NDPServe.dll?ViewItem?SignIn=Sign%20in%20as%20Guest&ItemID=2325 | ||
| DATASET DESCRIPTION | ||
| Mouse number 1503
Low dose Americium. Carcinoma NOS. salivary gland. | ||
| DATASET NAME | ||
|---|---|---|
| Publications from Project | ||
| DOI | DOI:10.20348/STOREDB/1014/1023 | |
| DATASET DESCRIPTION | ||
| List of publications arising from the project | ||
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