STUDYID | STOREDB:STUDY1054 |
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CREATEDON | 2016-10-18 11:43:52 |
MODIFIEDON | 2016-10-18 11:43:52 |
UPLOADER | Michael Gruenberger |
DOI | DOI:10.20348/STOREDB/1054 |
STUDY NAME | ||
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Lung Tumours in Rats After Inhalation of Radon and Application of Different Minerals | ||
STUDY STATUS | ||
Published: Open access to everyone | ||
COUNTRY | ||
France | ||
PRINCIPAL INVESTIGATOR | ||
Dr. Michele Morin | ||
SPECIES | ||
Rattus | ||
BIOLOGICAL SAMPLE AVAILABLE | ||
No | ||
STUDY DESCRIPTION | ||
Purpose: To determine the risks of lung tumors after radon inhalation together with various minerals
Status: 1968- 1984, terminated; data in ERAD except those indicated in red Treatment: Inhalation of radon (0.1-0.3 μm AMAD 6.2% unattached), inhalation, or intra-pleural or intra-tracheal injection different minerals, for further details see individual experiments below. Dosimetry: Activity inhaled (dose from daughter products deposited 2-3 mGy/WLM) Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology unless otherwise stated below Animal: Male Sprague-Dawley SPF rats of different ages as indicated below; controls see 02.01 Results: The influence of different fibrous minerals, given either directly or in a lixified state, on the carcinogenic effect of radon was studied because some of these minerals are known to cause pleural mesotheliomas in man. In first series of experiments, no synergism was found between radon and different fibrous minerals (chrysotile, crocydolite, amosite which had been lixified). but these minerals caused pleural mesotheliomas. In another experimental series, attapulquite, mucipulguite, gastropulquite showed no synergistic effect and did not cause any mesothelioma. The same experimental design applied to hematite, quartz DQ12 or beryllium also did not indicate any synergism. |
DATASET NAME | ||
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Link to data and details in ERA | ||
DOI | DOI:10.20348/STOREDB/1054/1092 | |
LINK TO FILE | ||
https://era.bfs.de/studies_details.php?LabId=2&StudyId=5 |