STORE_DB

STUDY NAME
	Institute of Environmental Studies database
STUDY STATUS
	Published: Open access to everyone

DATA SHARING POLICY
	Other (specify in 'description')

COUNTRY
	Japan

PRINCIPAL INVESTIGATOR
	Ignatia Braga-Tanaka
SPECIES
	Mus musculus

SIZE OF COHORT
	10000-99999

OUTCOME
	Cancer

RADONORM RESEARCH PRIORITY
	Analysis of mechanisms involved in low dose radiation through use and development of suitable cellular and animal models

INTERNAL OR EXTERNAL EXPOSURE
	External

TYPE OF EXTERNAL EXPOSURE
	gamma

EXPOSURE PATTERN
	Protracted

DOSE RATE
	Low

BIOLOGICAL SAMPLE AVAILABLE
	Yes
ECOLOGICAL DATA
	No
STUDY DESCRIPTION
	For the past 22 years the Institute of Environmental studies (IES) in Rokkasho, Aomori prefecture, Japan has been studying the biological effects of long-term external exposure in mice (Braga-Tanaka et al. 2018). The facility at the IES is important in its ability to deliver low doses over the complete lifetime of an experimental animal. Dose rates of 0.05-1 mGy over 400 days, comparable to the doses accumulated by radiation workers. Mice subsequently analysed for lifespan compromise, cancer and other disease plus chromosome abnormalities and transgenerational effects. The accumulated datasets and biological specimens represent a major resource for chronic dose effect assessment and have an important input into the determination of safety limits and risk, especially for occupational exposure.
PUBMED ID
	29533133