# Skinbase

##### Mouse Skin and Hair Database

## Fuzzy (fz) Chr1

- Mild follicular dystrophy is present in histologic sections of fuzzy mutant mice.
- Plucked hairs from a fuzzy mutant mouse. Note the high degree of waviness of all the fiber types. All 4 truncal hair fiber types are present in this mutant mouse.
- Higher magnification of figure 49 reveals the degree of waviness of the hair fiber types.
- Scanning electron micrograph of a hair fiber from a fuzzy mutant mouse. Note the flattened fiber causes the waviness.

The fuzzy mutation arose spontaneously in 1945 in the CFW stock of Dr. Canochan at the Carworth Farms. An allele (fz2J) arose spontaneously in 1979 in the AKR/J strain at The Jackson Laboratory. Additional alleles have been found either arising spontaneously or in ENU mutagenesis programs. The gene was originally mapped to Chr. 1, 5 cM from the centromere. The mutation appears to have been identified and this should be published in the near future.
Mutant mice can be identified as early as 6 days of age by the presence of thin and wavey vibrissae and an uneven hair coat over the body. Plucked hairs are wavy with many areas that are flattened to form constrictions at bends. Early studies found abnormalities in the dermal papilla within anagen hair follicles and scattered dilated piliary canals filled with hair fiber debris.

### References

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