# Skinbase

##### Mouse Skin and Hair Database

## Beige Lysosomal trafficing regulator (Lyst-bg) Chr13

- Normal banding and pigment pattern in a guard hair from a C57BL/6J +/+ mouse.
- Pigment clumping in a zigzag hair from a C57BL/6J- LystbgJ/LystbgJ mouse.
- Normal retinal and iris pigment in a C57BL/6J +/+ mouse eye. 10X.
- Normal retinal pigment in a C57BL/6J +/+ mouse eye. 40X.
- Normal iris pigment in a C57BL/6J +/+ mouse eye. 40X.
- Abnormal retinal and iris pigment in a C57BL/6J LystbgJ/LystbgJ mouse eye. 10X.
- Abnormal retinal pigment in a C57BL/6J LystbgJ/LystbgJ mouse eye. 40X.
- Abnormal iris pigment in a C57BL/6J LystbgJ/LystbgJ mouse eye. 40X.
- Normal renal tubules in a C57BL/6J +/+ mouse kidney. PAS stain.
- Normal renal tubules in a C57BL/6J +/+ mouse kidney. H&E
- Normal renal tubules in a C57BL/6J +/+ mouse kidney. H&E
- Abnormal renal tubules in a C57BL/6J LystbgJ/LystbgJ mouse kidney. PAS stain.
- Abnormal renal tubules in a C57BL/6J LystbgJ/LystbgJ mouse kidney. H&E
- Abnormal renal tubules in a C57BL/6J LystbgJ/LystbgJ mouse kidney. H&E

Beige, Lysosomal trafficing regulator (Lystbg), Chr. 13, 7.0 cM, Genome Coordinates: 12940095-13078389
Many people are confused when they see a beige mouse for the first time. Most consider beige to be a light brown color. To their surprise the mice are essentially black. This is because the original mutation occurred in as a radiation-induced mutation at the Oak Ridge National Laboratory on an agouti black background. The mutant mice had a cafe au lait or beige color. A remutation in this locus arose spontaneously at The Jackson Laboratory in the C57BL/6J inbred strain, which is black. As this mutation causes a coat color dilution, these mice were described as dark (charcoal) grey colored. This is the mutant most commonly used today.
Coat, skin, and eye color dilution is the phenotype most obvious with these mice. This is due to the reduced number, enlargement, and clumping of melanin granules. Other cell types are also affected that have granules. These include granulocytes, lymphocytes, hepatocytes, renal proximal tubules, central nervous system, exocrine and endocrine pancreas, ducts of various glands, thyroid follicles, type II pneumocytes, and mast cells.

### References

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Lane PW, bg<2J> - beige-2J, Mouse News Lett 1962;26():35
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Lyon MF; Meredith R, [Slate allelic to beige.], Mouse News Lett 1965;33():29
Lutzner MA; Lowrie CT; Jordan HW, Giant granules in leukocytes of the beige mouse., J Hered 1967 Nov-Dec;58(6):299-300
Lane PW; Murphy ED, Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice., Genetics 1972 Nov;72(3):451-60
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Roths JB; Murphy ED, The beige mutation retards the progression of autoimmune disease., Jackson Lab Ann Rep 1982;53():65
Saxena RK; Saxena QB; Adler WH, Defective T-cell response in beige mutant mice., Nature 1982 Jan 21;295(5846):240-1
Orn A; Hakansson EM; Gidlund M; Ramstedt U; Axberg I; Wigzell H; Lundin LG, Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity., Scand J Immunol 1982 Mar;15(3):305-10
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Takeuchi K; Wood H; Swank RT, Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G., J Exp Med 1986 Mar 1;163(3):665-77
Pak MW; Giolli RA; Pinto LH; Mangini NJ; Gregory KM; Vanable JW Jr, Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl., J Comp Neurol 1987 Apr 15;258(3):435-46
Holcombe RF; Strauss W; Owen FL; Boxer LA; Warren RW; Conley ME; Ferrara J; Leavitt RY; Fauci AS; Taylor BA; Seidman JG, Relationship of the genes for Chediak-Higashi syndrome (beige) and the T-cell receptor gamma chain in mouse and man., Genomics 1987 Nov;1(3):287-91
Holcombe RF; Stephenson DA; Zweidler A; Stewart RM; Chapman VM; Seidman JG, Linkage of loci associated with two pigment mutations on mouse chromosome 13., Genet Res 1991 Aug;58(1):41-50
Guo H; Sekiguchi M; Shimai K, Cytoarchitectonic abnormalities in cerebellum and hippocampal formation of beige mutant mouse., Tokai J Exp Clin Med 1992 May;17(1):53-61
Hua C; Chang B; Ma B-L; Li Y; Wang G, Reduction of lymphokine-activated killer cell activity by the introduction of the beige gene into SCID mice, ILAR News 1992;34(1-2):S15-S16
Whitney PL; Starcher B; Brittain C, Soluble beta-galactoside specific lectin is developmentally regulated in lungs of neonatal black mice and beige mice., Exp Lung Res 1992 Jul-Aug;18(4):553-61
Gross SK; Lyerla TA; Williams MA; McCluer RH, The accumulation and metabolism of glycosphingolipids in primary kidney cell cultures from beige mice., Mol Cell Biochem 1992 Dec 2;118(1):61-6
Mosier DE; Stell KL; Gulizia RJ; Torbett BE; Gilmore GL, Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation., J Exp Med 1993 Jan 1;177(1):191-4
Percy DH; Barta JR, Spontaneous and experimental infections in scid and scid/beige mice., Lab Anim Sci 1993 Apr;43(2):127-32
Perou CM; Kaplan J, Complementation analysis of Chediak-Higashi syndrome: the same gene may be responsible for the defect in all patients and species., Somat Cell Mol Genet 1993 Sep;19(5):459-68
Tanaka E; Yuba Y; Sato A; Kuze F, Effects of the beige mutation on respiratory tract infection with Pseudomonas aeruginosa in mice., Exp Lung Res 1994 Jul-Aug;20(4):351-66
Sundberg JP, The Beige (bg) Mutation, Chromosome 13, In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. Sundberg, JP (ed.), CRC Press, Boca Raton, FL, pp 203-210, 1994
Jones-Carson J; Vazquez-Torres A; Balish E, Defective killing of Candida albicans hyphae by neutrophils from beige mice., J Infect Dis 1995 Jun;171(6):1664-7
Barthold SW; de Souza M, Exacerbation of Lyme arthritis in beige mice., J Infect Dis 1995 Sep;172(3):778-84
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Fukai K; Oh J; Karim MA; Moore KJ; Kandil HH; Ito H; Burger J; Spritz RA, Homozygosity mapping of the gene for Chediak-Higashi syndrome to chromosome 1q42-q44 in a segment of conserved synteny that includes the mouse beige locus (bg)., Am J Hum Genet 1996 Sep;59(3):620-4
Kingsmore SF; Barbosa MD; Nguyen QA; Ashley JA; Blaydes SM; Tchernev VT; Detter JC ; Lovett M, Physical mapping of the beige critical region on mouse chromosome 13., Mamm Genome 1996 Oct;7(10):773-5
Kingsmore SF; Barbosa MD; Tchernev VT; Detter JC; Lossie AC; Seldin MF; Holcombe RF, Positional cloning of the Chediak-Higashi syndrome gene: genetic mapping of the beige locus on mouse chromosome 13., J Investig Med 1996 Oct;44(8):454-61
Perou CM; Perchellet A; Jago T; Pryor R; Kaplan J; Justice MJ, Comparative mapping in the beige-satin region of mouse chromosome 13., Genomics 1997 Jan 15;39(2):136-46
Misumi DJ; Nagle DL; McGrail SH; Dussault BJ Jr; Smutko JS; Chen H; Charlat O; Duyk GM; Ebeling C; Baldini L; Carlson GA; Moore KJ, The physical and genetic map surrounding the Lyst gene on mouse chromosome 13., Genomics 1997 Feb 15;40(1):147-50
Jensen BL; Rasch R; Nyengaard JR; Skott O, Giant renin secretory granules in beige mouse renal afferent arterioles., Cell Tissue Res 1997 May;288(2):399-406
Barbosa MD; Barrat FJ; Tchernev VT; Nguyen QA; Mishra VS; Colman SD ; Pastural E ; Dufourcq-Lagelouse R ; Fischer A ; Holcombe RF ; Wallace MR ; Brandt SJ ; de Saint Basile G ; Kingsmore SF, Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse., Hum Mol Genet 1997 Jul;6(7):1091-8
Sundberg JP; Sundberg BA; Beamer WG, Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen., Mol Carcinog 1997 SEP;20(1):19-32
Davis SG; Lyerla TA, The effect of lysosomotropic amines on beige mouse cells., Exp Cell Res 1997 Nov 25;237(1):242-5
Perou CM; Leslie JD; Green W; Li L; Ward DM; Kaplan J, The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein., J Biol Chem 1997 Nov 21;272(47):29790-4
Spritz RA, Genetic defects in Chediak-Higashi syndrome and the beige mouse., J Clin Immunol 1998 Mar;18(2):97-105
McGarry MP; Reddington M; Novak EK; Swank RT, Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome., Proc Soc Exp Biol Med 1999 Mar;220(3):162-8
Peters LL; Gwynn B; Wilson LA; Schimenti J, A remutation at the beige (Lyst) locus arising in an ethylnitrosourea mutagenesis screen, MGI Direct Data Submission 2003;():
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