| STUDYID | STOREDB:STUDY1015 |
|---|---|
| CREATEDON | 2015-12-10 16:26:47 |
| MODIFIEDON | 2015-12-10 16:26:47 |
| UPLOADER | Michael Gruenberger |
| DOI | DOI:10.20348/STOREDB/1015 |
| STUDY NAME | ||
|---|---|---|
| GENRISK-T (FP6-36495) Iodine131-induced Thyroid Tumours in Mice | ||
| STUDY STATUS | ||
| Published: Open access to everyone | ||
| COUNTRY | ||
| Germany | ||
| PRINCIPAL INVESTIGATOR | ||
| Dr. Claudia Dalke | ||
| SPECIES | ||
| Mus musculus | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| Yes | ||
| STUDY DESCRIPTION | ||
| To determine the extend to which individual genetic differences influence the risk of developing thyroid cancer after exposure to radiation.Genetic factors can modify susceptibility to the carcinogenic effect of ionising radiation. To establish if radioiodine-induced thyroid cancer is similarly genetically influenced, we studied F1 hybrid crosses between inbred mouse strains. Mice were perinatally exposed to iodine-131 and thyroid tissues examined after 18 months. Differences in the incidence and distribution of histological subtypes were quantified in relation to genetic background. | ||
| DATASET NAME | ||
|---|---|---|
| Thyroid lesions in iodine-131 treated and unirradiated control mice. | ||
| DOI | DOI:10.20348/STOREDB/1015/1029 | |
| DATASET DESCRIPTION | ||
| Distribution of hyperplastic and neoplastic thyroid lesions in iodine-131 treated and unirradiated control mice.Different hybrid mice from F1 crosses of C3H ×C57BL/6 (C3B6F1), BALB/c × C3H (CC3F1) and JF1 × C3H (JFC3F1) were studied. | ||
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File size: 55 kilobytes
Uploaded on: 2020-09-24 16:45:47
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