|Lung Tumours in Rats After Inhalation of Radon and Treatment with Different Cofactors
|Published: Open access to everyone
|Dr. Michele Morin
|BIOLOGICAL SAMPLE AVAILABLE
|Purpose: To determine the risks of lung tumors after inhalation of radon in combination with treatment with various cofactors.
Status: 1973- ongoing; data in ERAD
Treatment: Inhalation of radon (0.1-0.3 μm AMAD 6.2% unattached), treatment with radiation, radionuclides or different cofactors, for details see individual experiments below.
Dosimetry: Activity inhaled (dose from daughter products deposited 2-3 mGy/WLM), for Triton see 02.14
Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology unless otherwise stated below
Animal: Male Sprague-Dawley SPF rats of different ages as indicated below
Results: Several pharmaceutical active agents were given together with radon exposure to test whether, on the one hand, certain of these substances (eg cyclophosphamide, bleomycine, methotrexate) would reduce the incidence of cancer, or, on the other hand, whether such substances when used for different therapeutic purposes (eg rifampicine, BCG, isoniazide, endoxan, largactil, phenobarbitol) could act as cofactors for radon-induced cancer. None of the substances had any positive or negative effect on the rate of incidence of radon-induced lung cancer. Alcohol also had no effect whatsoever.
|Link to data and details in ERA
|LINK TO FILE