STUDYID | STOREDB:STUDY1070 |
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CREATEDON | 2017-04-24 14:00:56 |
MODIFIEDON | 2017-04-24 14:00:56 |
UPLOADER | Michael Gruenberger |
DOI | DOI:10.20348/STOREDB/1070 |
STUDY NAME | ||
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Brain Damage in 90 Day-old Rats Exposed During the Entire Gestation to Co-90 Gamma Rays or Cf-252 Neutrons At Different Dose Rates | ||
STUDY STATUS | ||
Published: Open access to everyone | ||
COUNTRY | ||
France | ||
PRINCIPAL INVESTIGATOR | ||
Dr Coffigny | ||
SPECIES | ||
Rattus | ||
BIOLOGICAL SAMPLE AVAILABLE | ||
No | ||
STUDY DESCRIPTION | ||
Purpose: To determine the effect of dose rate and relative biological efficiency of neutron vs gamma irradiation for protracted, in utero exposure
Status: 1989 - 1992, terminated Treatment: Protracted Co-60 gamma irradiation and Cf-252 neutrons plus gamma (ratio 2/1) irradiation at different dose rates delivered over the entire gestation Dosimetry: Gamma: ionization chamber; neutrons: ionization chamber filled with circulating tissue-equivalent gas Endpoints: Early and late effects on brain weight and late effects on brain histology Animal: Sprague-Dawley SPF rats offspring Results: Ninety day old rats exposed during the entire gestation to C0-60 gamma rays or Cf-252 neutrons at various dose rates showed a marked decrease in brain weight (RBE = 4) but no gross malformations of the brain when examined by histological methods. |
DATASET NAME | ||
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Link to data and details in ERA | ||
DOI | DOI:10.20348/STOREDB/1070/1110 | |
LINK TO FILE | ||
https://era.bfs.de/studies_details.php?LabId=2&StudyId=17 |