|Ovarian tumours in mice after X-ray and neutron exposure
|Published: Open access to everyone
|BIOLOGICAL SAMPLE AVAILABLE
|Purpose: To determine the dose relationship and RBE for ovarian murine tumors after X-ray and neutron exposure.
Status: 1982 - 1987, terminated, data in ERAD
Treatment: Single acute exposure to 250 kVp X-rays (1.5 mm HVL, 60 mGy/min) or 1.5 MeV neutrons from a van de Graaff accelerator at the JRC Ispra (1.83 mGy/min)
Dosimetry: Twin ionization chamber method, ENDIP
Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology
Animal: Female (C57Bl/Cne x C3H/Cne)F1 (BC3F1) mice aged 3 months
Results: A significant increase in life-shortening was observed for single neutron exposure to 0.08 Gy. or more. Assuming a linear non-threshold dose-effect relationship, the RBE value is 12.3 for 1.5 MeV neutrons. A statistically significant increase in solid tumors is seen for single neutron exposure from 0.08 Gy and for X-ray exposure from 1 Gy. The data for neutrons at low doses can be fitted to a linear dose effect relationship. A separate analysis of of ovarian tumor induction substantiates the hypothesis of a threshold for X-rays, whereas such a threshold is not evident for neutrons. A trend analysis confirms these findings. When death rates are analyzed, a general agreement between their shift to earlier times and tumor induction was found.
|Link to data and details in ERA
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