| STUDYID | STOREDB:STUDY1082 |
|---|---|
| CREATEDON | 2017-05-03 10:45:10 |
| MODIFIEDON | 2017-05-03 10:45:10 |
| UPLOADER | Michael Gruenberger |
| DOI | DOI:10.20348/STOREDB/1082 |
| STUDY NAME | ||
|---|---|---|
| Liver and Spleen Tumours in Rats After Injection of Th-230 Enriched Thorotrast | ||
| STUDY STATUS | ||
| Published: Open access to everyone | ||
| COUNTRY | ||
| Germany | ||
| PRINCIPAL INVESTIGATOR | ||
| Prof. Wesch | ||
| SPECIES | ||
| Rattus | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| Yes | ||
| STUDY DESCRIPTION | ||
| Purpose: To determine the respective roles of the radioactive and chemical component in Thorotrast gel-induced tumours, alpha radioactivity in Thorotrast was enriched about 50 times by addition of Th-230.
Status: 1975-1979, terminated Treatment: Single i.v. injection with different amounts of variously enriched Thorotrast (see below) Dosimetry: Activity delivered Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Female Wistar rats aged 12±2 weeks at injection. Results: The number of animals that developed liver or spleen tumours increased by a factor of 19 in the highest dose-rate groups compared to controls. There was a linear correlation between dose rate and the number of liver and spleen tumours. An increase of the number of injected Thorotrast particles, providing a constant dose rate, had little influence on tumour incidence. However, at a constant relative dose-rate of ten, a fifty-fold increase in the number of particles (12-600 μl) shortened the minimal tumour latency time by about 250 days. The induced liver tumours showed mostly the same morphology as those observed in Thorotrast patients except for a special type of sarcoma which, so far, has not been seen in man and was interpreted as a Kupffer cell sarcoma. No excess lung tumours due to the exhalation of Rn-220 was observed. FFPE Blocks are available at HMGU. | ||
| DATASET NAME | ||
|---|---|---|
| Link to data and details in ERA | ||
| DOI | DOI:10.20348/STOREDB/1082/1122 | |
| LINK TO FILE | ||
| https://era.bfs.de/studies_details.php?LabId=4&StudyId=1 | ||