| STUDYID | STOREDB:STUDY1083 |
|---|---|
| CREATEDON | 2017-05-03 10:47:50 |
| MODIFIEDON | 2017-05-03 10:47:50 |
| UPLOADER | Michael Gruenberger |
| DOI | DOI:10.20348/STOREDB/1083 |
| STUDY NAME | ||
|---|---|---|
| Lung Tumours in Rats After Injection of Normal and Th-228 Enriched Thorotrast and Inhalation of Quartz Dusts | ||
| STUDY STATUS | ||
| Published: Open access to everyone | ||
| COUNTRY | ||
| Germany | ||
| PRINCIPAL INVESTIGATOR | ||
| Prof. Wesch | ||
| SPECIES | ||
| Rattus | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| Yes | ||
| STUDY DESCRIPTION | ||
| Purpose: To determine whether thoron exhaled from incorporated Thorotrast whose alpha radioactivity was enriched about 25 times in some groups by an addition of Th-228 would cause lung tumours if combined with inhalation of quartz dust.
Status: 1986-1989, terminated Treatment: Single i.v. injection of 600 μl enriched Thorotrast (1776 Bq Th-228/ml) followed by inhalation of quartz dust (6 mg/m3 or 30 mg/m 3) over 29 days Dosimetry: Activity injected Endpoints: Serial killing (0, 6, 12, and 24 months after exposure) and life-span (spontaneous death) with macroscopic/microscopic pathology Animal: Female Wistar rats aged 3 ± 0.5 months at injection. Results: In all quartz-exposed groups, the incidence of lung tumours was greater than 40%, The additional Thorotrast treatment resulted in a marked reduction of tumour latency times and in a higher total incidence (65%) in the animals exposed to the high quartz level (30 mg/m3. Eighty seven of the animals treated with Thorotrast only developed lung tumours. Statistical methods that correct for intercurrent mortality showed a significant increase of the lung tumour risk due to Thorotrast even for the groups receiving the lowest concentration of quartz. The study demonstrates a pronounced interaction between quartz and Thorotrast in lung carcinogenesis. FFPE Blocks are available at HMGU. | ||
| DATASET NAME | ||
|---|---|---|
| Link to data and details in ERA | ||
| DOI | DOI:10.20348/STOREDB/1083/1123 | |
| LINK TO FILE | ||
| https://era.bfs.de/studies_details.php?LabId=4&StudyId=2 | ||