|Lung Tumours in Rats After Injection of Normal and Th-228 Enriched Thorotrast and Inhalation of Quartz Dusts
|Published: Open access to everyone
|BIOLOGICAL SAMPLE AVAILABLE
|Purpose: To determine whether thoron exhaled from incorporated Thorotrast whose alpha radioactivity was enriched about 25 times in some groups by an addition of Th-228 would cause lung tumours if combined with inhalation of quartz dust.
Status: 1986-1989, terminated
Treatment: Single i.v. injection of 600 μl enriched Thorotrast (1776 Bq Th-228/ml) followed by inhalation of quartz dust (6 mg/m3 or 30 mg/m 3) over 29 days
Dosimetry: Activity injected
Endpoints: Serial killing (0, 6, 12, and 24 months after exposure) and life-span (spontaneous death) with macroscopic/microscopic pathology
Animal: Female Wistar rats aged 3 ± 0.5 months at injection.
Results: In all quartz-exposed groups, the incidence of lung tumours was greater than 40%, The additional Thorotrast treatment resulted in a marked reduction of tumour latency times and in a higher total incidence (65%) in the animals exposed to the high quartz level (30 mg/m3. Eighty seven of the animals treated with Thorotrast only developed lung tumours. Statistical methods that correct for intercurrent mortality showed a significant increase of the lung tumour risk due to Thorotrast even for the groups receiving the lowest concentration of quartz. The study demonstrates a pronounced interaction between quartz and Thorotrast in lung carcinogenesis.
FFPE Blocks are available at HMGU.
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