Study meta-data

STUDYID	STOREDB:STUDY1091
CREATEDON	2017-05-19 13:52:55
MODIFIEDON	2017-05-19 14:00:20
UPLOADER	Paul Schofield
DOI	DOI:10.20348/STOREDB/1091

Study details

STUDY NAME
	3-generation Exposure Study
STUDY STATUS
	Published: Open access to everyone
DATA SHARING POLICY
	Other (specify in 'description')
COUNTRY
	Kazakhstan
PRINCIPAL INVESTIGATOR
	Prof. Kazbek N. Apsalikov
SPECIES
	Homo sapiens
SIZE OF COHORT
	1000-9999
OUTCOME
	Transgenerational effects
EXPOSURE CONTEXT
	Environmental
INTERNAL OR EXTERNAL EXPOSURE
	External
TYPE OF EXTERNAL EXPOSURE
	mixed
TYPE OF INTERNAL EXPOSURE
	mixed
RADIONUCLIDE
	multiple
DOSE RATE
	Mixed
BIOLOGICAL SAMPLE AVAILABLE
	Yes
STUDY DESCRIPTION
	The Semipalatinsk nuclear test site (STS) is located approximately 150 km west of the city of Semipalatinsk (now called Semey), and was a major site for nuclear weapons testing by the former Soviet Union. It was here that the Soviet Union conducted their first nuclear test on 29 August 1949. Later, 465 nuclear explosions were carried out between 1949 and 1989, including 118 atmospheric events (88 air events and 30 surface events) from 1949-1962. The last event was conducted at the STS on 19 October 1989. The total yield of atmospheric events conducted at STS is reported to be 6.58 megatons of TNT equivalent, which corresponds to approximately 66% of the total es mated Soviet bomb yield. The Research Institute for Radiation Medicine and Ecology in Semey, Kazakhstan, runs a registry of the population living around STS. It is the successor of the 1957-founded medical ins tu on Dispensary No. 4 of the USSR Ministry of Health whose activities included studies on the health effects of radiation exposure to those residing adjacent to the STS. In 2014, the Institute started collecting information on 8,400 persons from the Register, setting up the basis for a three -generation study. The following data are abstracted: a) registration data: individual’s ID, sex, nationality, date and place of birth; b) medical information (where applicable): diagnoses names and dates, congenital malformations, cause of death; c) dosimetry data: radiation route, radiation dose (based on doses assigned by Kazakh legislation, which can differ from the doses estimated by other methods); d) information on lifestyle factors: smoking, alcohol; availability of biological samples: blood, DNA, tumour and normal tissues. This information is included in the STORE database (AIR2, #3). Of the 8,400 individuals registered, 2,380 were affected by the test, 2,937 belong to the F1 generation and 3,083 to the F2 genera on. Overall, the following information is available: 11,327 medical diagnosis for incident cases, 1,199 causes of death, 1,937 smoking information, 2,982 drinking information, 215 blood samples, 79 DNA, 14 cancer and 14 healthy tissue samples, and for 145 information on chromosomal aberrations. Data are available through STORE by agreement with the data curators. Reference: Susanne Bauer, Boris Gusev, Tatyana Belikhina, Timur Moldagaliev, Kazbek Apsalikov, The Legacies of Soviet Nuclear Testing in Kazakhstan, Radioactivity in the Environment, Volume 19, 2013, Pages 241-258, ISSN 1569-4860, https://doi.org/10.101/B978-0-08-045015-5.00014-9