|Chernobyl Tissue Bank
|Published: Open access to everyone
|DATA SHARING POLICY
|Other (specify in 'description')
|Prof Gerry Thomas
|SIZE OF COHORT
|INTERNAL OR EXTERNAL EXPOSURE
|TYPE OF INTERNAL EXPOSURE
|AGE AT EXPOSURE
|BIOLOGICAL SAMPLE AVAILABLE
|The Chernobyl Tissue Bank (CTB) was established in 1998 to collect, store and distribute biological samples from patients born on or after 26th April 1967, and resident in the regions of Ukraine and Russia contaminated by fallout from the Chernobyl accident and who developed thyroid cancer. The current collec,on comprises 4500 cases of thyroid cancer and adenoma. 3094 of the 4500 cases are from the exposed areas of Ukraine and Russia, whereas 1406 cases come from the unexposed areas of Ukraine and Russia. There are also 758 post Chernobyl cases (born after 1st December 1986) from Ukraine and Russia: 475 cases are from the exposed areas and a further 283 are from unexposed areas. A thyroid dose is estimated for each case once the pathology consensus diagnosis is agreed. The colletction includes samples from the Ukraine-American cohort.
A sample of blood for extraction of DNA, serum and samples of both frozen (where the tumour is large enough) and formalin fixed paraffin embedded (FFPE) tumour and normal thyroid tissue are provided by each patient. The pathology of every case submitted to the CTB is reviewed by an international panel of pathologists. Molecular biology quality assurance (QA) is carried out on each sample prior to release to researchers. In order to maximise the use of the resource, nucleic acids are ex- tracted from the same frozen tissue block, aliquoted and are distributed to multiple researchers. Individual sections from FFPE blocks from individual cases are also issued to multiple re-searchers. Researchers apply for material through an online portal (https://cisbic.bioinforma,cs.ic.ac.uk/ctb/ html_ctb_public/). Applications are reviewed by an independent external review panel, thus ensuring that the material is used appropriately in first class scientific research. Researchers agree to provide data from their studies back to the project in order that these can be integrated into future studies.
|Chernobyl Tissue Bank
|LINK TO FILE
|Data available on application from curator.