STOREDB:STUDY1138 Radiobiological Archive of Large-scale Animal Experiments at QST-NIRS: J-SHARE [DOI:10.20348/STOREDB/1138]
|Radiobiological Archive of Large-scale Animal Experiments at QST-NIRS: J-SHARE|
|Published: Open access to everyone|
|DATA SHARING POLICY|
|SIZE OF COHORT|
|INTERNAL OR EXTERNAL EXPOSURE|
|TYPE OF EXTERNAL EXPOSURE|
|BIOLOGICAL SAMPLE AVAILABLE|
|The Japanese Institutes for Quantum and Radiological Science and Technology (QST) and its National Institute of Radiological Sciences have had a program of large-scale external exposure of rodents to a variety of radiation qualities, X ray, γ, neutron and heavy ions using the Heavy Ion Medical Accelerator at Chiba (HIMAC). These experiments focus on cancer research and many of the experiments are lifespan studies, mostly on wild type or genetically manipulated inbred mice and rats. The QST-NIRS has decided to make their accumulated primary data on more than 13, 000 animals available through the J-Share database (Morioka et al., 2019 submitted). This database adds to the very large-scale mouse experiments discussed above with the exception not only containing legacy data but in principle will be augmented by new data from ongoing experiments. J-SHARE also includes an extensive archive of biological specimens. To date these consist of material from:
• Lifespan studies of 10,220 B6C3F1 male and female mice at different life stages, irradiated with gamma rays, carbon ions and neutrons.
• Studies on mammary gland and lung carcinogenesis with 2,200 Sprague Dawley female rats and 1,429 Wistar female rats, respectively.
• Studies on brain, digestive tract and renal tumorigenesis utilizing genetically-modified animals.
• Studies on the combined effect of radiation and chemicals.
• Studies for anticarcinogenic properties of caloric restriction and specific antioxidant nutrients and phytochemicals.
Frozen samples are retained along with experimental protocols, paraffin blocks, and histopathological slides. Digitisation of slides is being carried out to produce an archive of zoomable images using the Hamamatsu NanoZoomer. Embedded and frozen tissues are available for molecular analysis.