STOREDB:STUDY1163 Data collection and analysis on low dose hyper-radiosensitivity and induced radio-resistance [DOI:10.20348/STOREDB/1163]

Study meta-data


STUDYIDSTOREDB:STUDY1163
CREATEDON2021-01-12 14:04:22
MODIFIEDON2022-09-30 21:44:29
UPLOADERBalázs G. Madas
DOIDOI:10.20348/STOREDB/1163

Study details


STUDY NAME
Data collection and analysis on low dose hyper-radiosensitivity and induced radio-resistance
STUDY STATUS
Published: Open access to everyone
DATA SHARING POLICY
CC-Attribution
STUDY TYPE
12-01-00 - Cell culture study
COUNTRY
Hungary
PRINCIPAL INVESTIGATOR
Szabolcs Polgár, Paul Schofield, Balázs Madas
SPECIES
Multiple
SIZE OF COHORT
MELODI RESEARCH PRIORITY
Other activities contributing to low-dose risk research
INTERNAL OR EXTERNAL EXPOSURE
External
EXPOSURE PATTERN
Acute
DOSE RATE
Mixed
BIOLOGICAL SAMPLE AVAILABLE
No
ECOLOGICAL DATA
No
STUDY DESCRIPTION
There are hardly any raw experimental data which is easily available in the field of low dose hyper-radiosensitivity and induced radioresistance research. This is especially important in the case of mathematical modelling, where researchers usually do not perform experiments, but they would like to compare their results to the actual behaviour of the cells. The aim of this study is to collect datasets featuring experiments with various cell cultures showing hyper-radiosensitivity and induced radioresistance from published articles. The data are collected by manually reading each data point from the figures of the articles.

If you publish your research using this database, please cite the following reference:
Polgár, Sz., Schofield, P.N., Madas, B.G., 2022. Datasets of <i>in vitro</i> clonogenic assays showing low dose hyper-radiosensitivity and induced radioresistance. Sci Data 9, 555. https://doi.org/10.1038/s41597-022-01653-3

Acknowledgements
This study is part of a project that has received funding from the Euratom research and training programme 2019-2020 under grant agreement No 900009. The study was also supported by the Hungarian Research Data Alliance and the Library and Information Centre of the Hungarian Academy of Sciences (21-61), the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO-37-2021), and the ÚNKP-21-5 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (ÚNKP-21-5-BME-387).
PUBMED ID
36075916

STOREDB:DATASET1252 Second version of the database with 101 datasets from 46 articles published between 1993 and 2021 [DOI:10.20348/STOREDB/1163/1252]


Created on:2022-07-27 11:32:43
Modified On:2022-09-30 21:45:04
DATASET NAME
Second version of the database with 101 datasets from 46 articles published between 1993 and 2021
DOIDOI:10.20348/STOREDB/1163/1252
TASK
RadoNorm Task 4.5
DATASET DESCRIPTION
The second version of the database contains 101 datasets collected from 46 articles. The oldest article was published in 1993, and the newest in 2021. In each case, an identification number, the authors, the title, the year of publication, the digital object identifier (DOI), and the exact figure where the data was acquired from is given in column A. One dataset contains the surviving fraction of the cell culture (column C) at a given dose in Gy (column B) and the minimum (column D) and maximum value (column E) of the whiskers of the uncertainty of the surviving fraction. The parameters of the fitted function are also recorded if they are given in the article, either parameters of the Linear-Quadratic (LQ) model or the Induced Repair (IR) model or both. The fit type is given in column G. From column H to column X, different parameters (columns H, L, P, Q, U) are given with their standard deviations (columns I, M, R, V) or confidence limits (columns J, K, N, O, S, T, W, X). In column H, α refers to the LQ fit, while α<sub>r</sub> to the IR fit. If there are parameters or values which are not given in the articles (or no fits were made), then it is indicated with an ‘X’ symbol. If the parameters has no meaning for the given fit (for example the LQ model has only two parameters, α and β, so the others are not applicable), a ‘-‘ symbol is used. Red colour denotes those parameter values which we could not reproduce by fitting the models to the data collected. Properties of the cell line and characteristics of the irradiation are recorded in column Z and column AA, respectively.

The following articles were used to create the second version of the database:
https://doi.org/10.1080/09553009314450831
https://doi.org/10.2307/3578255
https://doi.org/10.2307/3578779
https://doi.org/10.2307/3579043
https://doi.org/10.2307/3579302
https://doi.org/10.1016/S0027-5107(96)00118-2
https://doi.org/10.1080/095530099139214
https://doi.org/10.1080/095530099139908
https://doi.org/10.1016/S0360-3016(00)01471-1
https://doi.org/10.1080/09553000210166606
https://doi.org/10.1093/oxfordjournals.rpd.a006772
https://doi.org/10.1093/oxfordjournals.rpd.a006777
https://doi.org/10.1667/RR3013
https://doi.org/10.1080/0955300021000045646
https://doi.org/10.1667/RR3060
https://doi.org/10.1002/ijc.11033
https://doi.org/10.1667/RR3130
https://doi.org/10.1016/j.ijrobp.2003.09.053
https://doi.org/10.1016/j.nimb.2005.11.120
https://doi.org/10.1667/RR3553.1
https://doi.org/10.1667/RR0776.1
https://doi.org/10.1269/jrr.07093
https://doi.org/10.1186/1748-717X-3-19
https://doi.org/10.1007/s00411-007-0145-9
https://doi.org/10.1667/RR1717.1
https://doi.org/10.3109/09553000903242107
https://doi.org/10.1007/s11596-009-0122-4
https://doi.org/10.1016/j.ijrobp.2010.01.028
https://doi.org/10.1259/bjr/33201506
https://doi.org/10.3109/09553002.2012.646046
https://doi.org/10.3109/09553002.2012.643274
https://doi.org/10.1093/jrr/rrs024
https://doi.org/10.1667/RR13358.1
https://doi.org/10.3109/09553002.2013.825061
https://doi.org/10.1016/j.ijrobp.2013.10.031
https://doi.org/10.7860/JCDR/2015/14120.6074
https://doi.org/10.1080/09553002.2016.1206235
https://doi.org/10.1016/j.dnarep.2015.12.001
https://doi.org/10.1158/1078-0432.CCR-18-0533
https://doi.org/10.1667/RR14208.1
https://doi.org/10.1016/j.dnarep.2021.103113
https://doi.org/10.1016/j.ijrobp.2009.04.088
https://doi.org/10.3389/fcell.2021.650819
https://doi.org/10.1016/j.nimb.2005.11.120
https://doi.org/10.1667/0033-7587(2000)154[0406:EOLDNA]2.0.CO;2
https://doi.org/10.1080/09553002.2017.1237057
study and dataset description v2.pdf

Type: application/pdf
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Uploaded on: 2022-09-30 21:45:44

database_v2.xlsx

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Uploaded on: 2022-07-29 18:11:09

STOREDB:DATASET1247 First version of the database with 101 datasets from 46 articles published between 1993 and 2021 [DOI:10.20348/STOREDB/1163/1247]


Created on:2021-11-15 16:27:03
Modified On:2021-12-06 21:22:48
DATASET NAME
First version of the database with 101 datasets from 46 articles published between 1993 and 2021
DOIDOI:10.20348/STOREDB/1163/1247
TASK
RadoNorm Task 4.5
DATASET DESCRIPTION
To create the first version of the database, we used overall 46 articles containing 101 datasets. The oldest article was published in 1993, and the newest in 2021. In each case, the authors, the title, the year of publication, the digital object identifier (DOI), and the exact figure from where the data was acquired is given in column A. One dataset contains the surviving fraction of the cell culture (column C) at a given dose in Gy (column B) and the minimum (column D) and maximum value (column E) of the whiskers of the standard deviation of the surviving fraction. The parameters of the fitted function were also recorded if they were given in the article, either parameters of the Linear-Quadratic (LQ) model or the Induced Repair (IR) model or both. The fit type is given in column G. From column H to column X, the different parameters (columns H, L, P, Q, U) are given with their standard deviations (columns I, M, R, V) or confidence limits (columns J, K, N, O, S, T, W, X). In column H, α refers to the LQ fit, while α<sub>r</sub> to the IR fit. If there were parameters or values which were not given in the articles (or no fits were made), then we indicated it with an ‘X’ symbol. If the parameters has no meaning for the given fit (for example the LQ model has only 2 parameters, α and β, so the others cannot be applied), we used a ‘-‘ symbol. Lastly, we recorded the cell type in column Z and the characteristics of the irradiation in column AA.

The following articles were used to create the first version of the database:
https://doi.org/10.1080/09553009314450831
https://doi.org/10.2307/3578255
https://doi.org/10.2307/3578779
https://doi.org/10.2307/3579043
https://doi.org/10.2307/3579302
https://doi.org/10.1016/S0027-5107(96)00118-2
https://doi.org/10.1080/095530099139214
https://doi.org/10.1080/095530099139908
https://doi.org/10.1016/S0360-3016(00)01471-1
https://doi.org/10.1080/09553000210166606
https://doi.org/10.1093/oxfordjournals.rpd.a006772
https://doi.org/10.1093/oxfordjournals.rpd.a006777
https://doi.org/10.1667/RR3013
https://doi.org/10.1080/0955300021000045646
https://doi.org/10.1667/RR3060
https://doi.org/10.1002/ijc.11033
https://doi.org/10.1667/RR3130
https://doi.org/10.1016/j.ijrobp.2003.09.053
https://doi.org/10.1016/j.nimb.2005.11.120
https://doi.org/10.1667/RR3553.1
https://doi.org/10.1667/RR0776.1
https://doi.org/10.1269/jrr.07093
https://doi.org/10.1186/1748-717X-3-19
https://doi.org/10.1007/s00411-007-0145-9
https://doi.org/10.1667/RR1717.1
https://doi.org/10.3109/09553000903242107
https://doi.org/10.1007/s11596-009-0122-4
https://doi.org/10.1016/j.ijrobp.2010.01.028
https://doi.org/10.1259/bjr/33201506
https://doi.org/10.3109/09553002.2012.646046
https://doi.org/10.3109/09553002.2012.643274
https://doi.org/10.1093/jrr/rrs024
https://doi.org/10.1667/RR13358.1
https://doi.org/10.3109/09553002.2013.825061
https://doi.org/10.1016/j.ijrobp.2013.10.031
https://doi.org/10.7860/JCDR/2015/14120.6074
https://doi.org/10.1080/09553002.2016.1206235
https://doi.org/10.1016/j.dnarep.2015.12.001
https://doi.org/10.1158/1078-0432.CCR-18-0533
https://doi.org/10.1667/RR14208.1
https://doi.org/10.1016/j.dnarep.2021.103113
https://doi.org/10.1016/j.ijrobp.2009.04.088
https://doi.org/10.3389/fcell.2021.650819
https://doi.org/10.1016/j.nimb.2005.11.120
https://doi.org/10.1667/0033-7587(2000)154[0406:EOLDNA]2.0.CO;2
https://doi.org/10.1080/09553002.2017.1237057
study and dataset description v1.pdf

Type: application/pdf
File size:

Uploaded on: 2021-12-06 21:14:24

database_v1.xlsx

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File size:

Uploaded on: 2021-12-02 14:57:14