| STUDYID | STOREDB:STUDY1239 |
|---|---|
| CREATEDON | 2026-07-06 12:43:06 |
| MODIFIEDON | 2026-07-06 13:39:58 |
| UPLOADER | Balázs G. Madas |
| DOI | DOI:10.20348/STOREDB/1239 |
| STUDY NAME | ||
|---|---|---|
| Mathematical modeling of low-dose hyper-radiosensitivity and induced radioresistance | ||
| STUDY STATUS | ||
| Published: Open access to everyone | ||
| STUDY TYPE | ||
| 09-13-00 - Mathematical Modelling study | ||
| DATA SHARING POLICY | ||
| CC-Attribution | ||
| COUNTRY | ||
| Hungary | ||
| PRINCIPAL INVESTIGATOR | ||
| Szabolcs Polgár, Balázs Madas | ||
| SPECIES | ||
| Multiple | ||
| RADONORM RESEARCH PRIORITY | ||
| Other activities contributing to low-dose risk research | ||
| INTERNAL OR EXTERNAL EXPOSURE | ||
| External | ||
| TYPE OF EXTERNAL EXPOSURE | ||
| mixed | ||
| EXPOSURE PATTERN | ||
| Acute | ||
| DOSE RATE | ||
| Mixed | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| No | ||
| ECOLOGICAL DATA | ||
| No | ||
| STUDY DESCRIPTION | ||
| Low-dose hyper-radiosensitivity (HRS) and induced radioresistance (IRR) are unexpected features of cellular survival curves that challenge classical radiobiological models. While often interpreted phenomenologically, their underlying biological purpose remains unclear. Here we propose that these effects reflect an evolved strategy by which tissues minimise mutational burden through context-dependent cell elimination. We introduce the Minimum Mutation Load (MML) model, a principle-based framework in which irradiated cells assess their survival based on local intercellular signals that reflect neighbourhood damage. This cooperative behaviour balances the benefit of removing highly damaged cells with the mutational cost of their replacement.
Acknowledgements This study is part of the RadoNorm project which has received funding from the Euratom research and training programme 2019–2020 under grant agreement No 900009. The study was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BGM, bo-37-2021), and the ÚNKP-22-5 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (BGM, ÚNKP-22-5-BME-299). | ||
| DATASET NAME | ||
|---|---|---|
| First version of the Minimum Mutation Load model | ||
| DOI | DOI:10.20348/STOREDB/1239/1362 | |
| LINK TO FILE | ||
| https://zenodo.org/records/20846430 | ||
| TASK | ||
| RadoNorm Task 3.6 | ||
| DELIVERABLE | ||
| RadoNorm Deliverable 3.6 | ||
| DATASET DESCRIPTION | ||
| A Jupyter notebook implementing the Minimum Mutation Load (MML) model for simulating clonogenic survival after irradiation. The model assigns radiation-induced mutagenic damage to individual cells and determines survival based on each cell’s damage relative to a distance-weighted signal from neighbouring cells.
The authors thank Márton Juhász for suggestions on the improvement of the readability of the Python code. | ||