STUDYID | STOREDB:STUDY1139 |
---|---|
CREATEDON | 2019-05-02 15:26:33 |
MODIFIEDON | 2019-05-02 15:26:33 |
UPLOADER | Paul Schofield |
DOI | DOI:10.20348/STOREDB/1139 |
STUDY NAME | ||
---|---|---|
Institute of Environmental Studies database | ||
STUDY STATUS | ||
Published: Open access to everyone | ||
DATA SHARING POLICY | ||
Other (specify in 'description') | ||
COUNTRY | ||
Japan | ||
PRINCIPAL INVESTIGATOR | ||
Ignatia Braga-Tanaka | ||
SPECIES | ||
Mus musculus | ||
SIZE OF COHORT | ||
10000-99999 | ||
OUTCOME | ||
Cancer | ||
RADONORM RESEARCH PRIORITY | ||
Analysis of mechanisms involved in low dose radiation through use and development of suitable cellular and animal models | ||
INTERNAL OR EXTERNAL EXPOSURE | ||
External | ||
TYPE OF EXTERNAL EXPOSURE | ||
gamma | ||
EXPOSURE PATTERN | ||
Protracted | ||
DOSE RATE | ||
Low | ||
BIOLOGICAL SAMPLE AVAILABLE | ||
Yes | ||
ECOLOGICAL DATA | ||
No | ||
STUDY DESCRIPTION | ||
For the past 22 years the Institute of Environmental studies (IES) in Rokkasho, Aomori prefecture, Japan has been studying the biological effects of long-term external exposure in mice (Braga-Tanaka et al. 2018). The facility at the IES is important in its ability to deliver low doses over the complete lifetime of an experimental animal. Dose rates of 0.05-1 mGy over 400 days, comparable to the doses accumulated by radiation workers. Mice subsequently analysed for lifespan compromise, cancer and other disease plus chromosome abnormalities and transgenerational effects. The accumulated datasets and biological specimens represent a major resource for chronic dose effect assessment and have an important input into the determination of safety limits and risk, especially for occupational exposure. | ||
PUBMED ID | ||
29533133 |