| STUDYID | STOREDB:STUDY1235 |
|---|---|
| CREATEDON | 2026-03-24 17:23:52 |
| MODIFIEDON | 2026-03-24 17:25:50 |
| UPLOADER | Emiliano Fratini |
| DOI | DOI:10.20348/STOREDB/1235 |
| STUDY NAME | ||
|---|---|---|
| Discover – MB Gene Expression | ||
| STUDY STATUS | ||
| Restricted: Downloaders have to ask uploader for file access | ||
| STUDY TYPE | ||
| 09-07-00 - Gene expression study | ||
| DATA SHARING POLICY | ||
| CC-Attribution Non-Commercial | ||
| COUNTRY | ||
| Italy | ||
| PRINCIPAL INVESTIGATOR | ||
| Simonetta Pazzaglia | ||
| SPECIES | ||
| Mus musculus | ||
| SIZE OF COHORT | ||
| 0-999 | ||
| OUTCOME | ||
| Cancer | ||
| RADONORM RESEARCH PRIORITY | ||
| Analysis of mechanisms involved in low dose radiation through use and development of suitable cellular and animal models | ||
| EXPOSURE CONTEXT | ||
| Medical | ||
| INTERNAL OR EXTERNAL EXPOSURE | ||
| External | ||
| TYPE OF EXTERNAL EXPOSURE | ||
| gamma | ||
| AGE AT EXPOSURE | ||
| Childhood | ||
| EXPOSURE PATTERN | ||
| Acute | ||
| DOSE RATE | ||
| High | ||
| BIOLOGICAL SAMPLE AVAILABLE | ||
| Yes | ||
| ECOLOGICAL DATA | ||
| No | ||
| STUDY DESCRIPTION | ||
| Bulk RNA sequencing was performed on medulloblastoma samples collected from Ptch1⁺/⁻ mice following neonatal γ irradiation (0 Gy, 0.1 Gy, 2 Gy). Libraries were generated from total RNA extracted from freshly dissected tumors. Sequencing was carried out on an Illumina platform, producing paired end reads (150 bp). Samples included tumors arising spontaneously (0 Gy) or following low dose (0.1 Gy) or high dose (2 Gy) irradiation, with metadata specifying irradiation dose, latency, sex, and experimental batch. The dataset includes raw FASTQ files, and associated sample information, enabling downstream differential expression analyses and integrative comparisons across dose groups. | ||
| MEAN DURATION OF FOLLOW-UP (WEEKS) | ||
| 60 | ||